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International Journal of Nanomedicine
Article . 2015 . Peer-reviewed
License: CC BY NC
Data sources: Crossref
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International Journal of Nanomedicine
Article
License: CC BY NC
Data sources: UnpayWall
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Clinical and pathological implications of miRNA in bladder cancer

Authors: Cornelia, Braicu; Roxana, Cojocneanu-Petric; Sergiu, Chira; Anamaria, Truta; Alexandru, Floares; Bogdan, Petrut; Patriciu, Achimas-Cadariu; +1 Authors

Clinical and pathological implications of miRNA in bladder cancer

Abstract

MicroRNAs (miRNAs) are small, noncoding RNA species with a length of 20–22 nucleotides that are recognized as essential regulators of relevant molecular mechanisms, including carcinogenesis. Current investigations show that miRNAs are detectable not only in different tissue types but also in a wide range of biological fluids, either free or trapped in circulating microvesicles. miRNAs were proven to be involved in cell communication, both in pathological and physiological processes. Evaluation of the global expression patterns of miRNAs provides key opportunities with important practical applications, taking into account that they modulate essential biological processes such as epithelial to mesenchymal transition, which is a mechanism relevant in bladder cancer. miRNAs collected from biological specimens can furnish valuable evidence with regard to bladder cancer oncogenesis, as they also have been linked to clinical outcomes in urothelial carcinoma. Therefore, a single miRNA or a signature of multiple miRNAs may improve risk stratification of patients and may supplement the histological diagnosis of urological tumors, particularly for bladder cancer.

Subjects by Vocabulary

Microsoft Academic Graph classification: medicine.disease_cause Bioinformatics microRNA medicine Epithelial–mesenchymal transition Pathological Bladder cancer business.industry Mechanism (biology) medicine.disease Non-coding RNA Microvesicles Carcinogenesis business

Keywords

Biophysics, diagnostic, Pharmaceutical Science, Bioengineering, Review, Biomaterials, Drug Discovery, Humans, miRNA, Organic Chemistry, General Medicine, Gene Expression Regulation, Neoplastic, MicroRNAs, Urinary Bladder Neoplasms, bladder cancer, prognostic

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
84
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Top 10%
Top 1%
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