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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Cianciosi, Alessandra;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Vian, Giovanni;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Caon, Fabio; Spaliviero, Camilla;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Frederic Blavier; Gilles Faron; Wilfried Cools; Christophe Blockeel; +6 Authors

    International audience; Objectives: In early pregnancies, miscarriages and inconclusive ultrasound scans considering location and viability are very common. In several previous studies, serum progesterone levels predicted viability of pregnancy and, in recent ones, failed Pregnancies of Unknown Location (PUL), completion of miscarriage and complications. Corpus luteum, secreting progesterone in early pregnancy, was less studied. Some publications showed correlations between corpus luteum aspects and diagnosis of miscarriage but it was not evaluated for other outcomes in early pregnancy, such as failed PUL, completion of miscarriage or complications. We aimed to assess if Doppler examination of corpus luteum could also predict all these outcomes: failed PUL, diagnosis and completion of miscarriages and complications.Study design: A single operator prospectively described and/or collected pictures of Doppler signal in the wall of the corpus luteum at most consultations in our early pregnancy unit and established a three-level score. All suspected or confirmed non-viable pregnancies with this score or/and serum progesterone levels were registered retrospectively. With logistic regressions, AIC/BIC, likelihood ratios, ROC curves, Mann-Whitney and Fisher exact tests, we evaluated the ability of the score, alone, to predict failed PUL, diagnosis and completion of miscarriages and the complications, and, combined, to improve previously published predictions.Results: From 277 included pregnancies, 186 (67.1 %) miscarried. Of these, 159/186 (85.5 %) fully evacuated without surgery: 114/186 (61.3 %) within 20 days after the first diagnosis and 45/186 (24.2 %) after more than 20 days. Twenty-seven patients (14.5 %) underwent surgical evacuation, including ten complications, five haemorrhages and five suspected infections. Logistic regression correlated strongly the corpus luteum score with failed PUL (p < 0.0001) and miscarriages (p < 0.0001). Moreover, rates of complications and swift non-surgical completions of miscarriage were respectively 0 % and 92 % with scores of 0, versus 6 % and 44 % with scores of 1, versus 16 % and 0 % with scores of 2. Combined with serum progesterone levels, this score improved most predictions. Adding parity or history of miscarriage in predictive models even increased these performances.Conclusions: Corpus luteum score, alone, can predict failed PUL, diagnosis and completion of miscarriages and their complications. Combining this score with other factors (mainly serum progesterone levels) improves most predictions.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HAL-Insermarrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    HAL-Inserm
    Other literature type . Article . 2021
    Data sources: HAL-Inserm
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    European Journal of Obstetrics & Gynecology and Reproductive Biology
    Article . 2021 . Peer-reviewed
    License: Elsevier TDM
    Data sources: Crossref
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao HAL-Insermarrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      HAL-Inserm
      Other literature type . Article . 2021
      Data sources: HAL-Inserm
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      European Journal of Obstetrics & Gynecology and Reproductive Biology
      Article . 2021 . Peer-reviewed
      License: Elsevier TDM
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Jabara, Enrico;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Journal of Group Theory
    Article . 2007 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of Group Theory
      Article . 2007 . Peer-reviewed
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: M. Giovanna Ranalli; Jean-François Beaumont; Gaia Bertarelli; Nathalie Shlomo;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    METRON
    Article . 2023 . Peer-reviewed
    License: Springer Nature TDM
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      METRON
      Article . 2023 . Peer-reviewed
      License: Springer Nature TDM
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Carlos Penarrubia; Jose J. Valero-Mas; Antonio Javier Gallego; Jorge Calvo-Zaragoza;

    Comunicació presentada a 11th Iberian Conference (IbPRIA 2023), celebrada del 27 al 30 de juny de 2023 a Alacant, Espanya. Prototype Generation (PG) methods seek to improve the efficiency of the k-Nearest Neighbor (kNN) classifier by obtaining a reduced version of a given reference dataset following certain heuristics. Despite being largely addressed topic in multiclass scenarios, few works deal with PG in multilabel environments. Hence, the existing proposals exhibit a number of limitations, being label imbalance one of paramount relevance as it constitutes a typical challenge of multilabel datasets. This work proposes two novel merging policies for multilabel PG schemes specifically devised for label imbalance, as well as a mechanism to prevent inappropriate samples from undergoing a reduction process. These proposals are applied to three existing multilabel PG methods—Multilabel Reduction through Homogeneous Clustering, Multilabel Chen, and Multilabel Reduction through Space Partitioning—and evaluated on 12 different data assortments with different degrees of label imbalance. The results prove that the proposals overcome—in some cases in a significant manner—those obtained with the original methods, hence validating the presented approaches and enabling further research lines on this topic. This work was supported by the I+D+i project TED2021-132103A-I00 (DOREMI), funded by MCIN/AEI/10.13039/501100011033.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao UPF Digital Reposito...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    UPF Digital Repository
    Conference object . 2023
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.1007/978-3-...
    Part of book or chapter of book . 2023 . Peer-reviewed
    License: Springer Nature TDM
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao UPF Digital Reposito...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      UPF Digital Repository
      Conference object . 2023
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      https://doi.org/10.1007/978-3-...
      Part of book or chapter of book . 2023 . Peer-reviewed
      License: Springer Nature TDM
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Gelichi, Sauro; Cadamuro, Silvia; Cianciosi, Alessandra;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Piva, Maria Chiara;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Archivio istituziona...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Grobin, Andrej;

    V okviru doktorske naloge smo celovito obravnavali problematiko obremenitve okolja s hormoni in nekaterimi drugimi pomembnimi kemičnimi motilci endokrinega sistema (KMES). Ugotovili smo, da so pomanjkljivi podatki o pojavnosti mnogih spojin in ekotoksikološkem potencialu (EP), še posebej sinteznih steroidov (SS). Na primeru bisfenola B smo pokazali, da je njegov EP podcenjen za vsaj štiri velikostne razrede. Zato smo za vrednotenje pojavnosti v okolju razvili ultra občutljivo analizno metodo za kvantitativno določanje prisotnosti kar 25 različnih KMES iz skupin naravnih hormonov, SS ter bisfenolov. Metodo smo validirali po obsežnem protokolu, ki smo ga predlagali za vpeljavo v validacijo tudi drugih okoljskih analiznih metod. Analizirali smo 36 vzorcev odpadnih in 33 povezanih rečnih vod (RV) in pri tem uspešno kvantificirali 16 KMES, z najvišjimi koncentracijami bisfenolov S, A in F ter estriola in klormadinona. Koncentracije nad priporočenimi varnimi vrednostmi smo določili tudi za estradiol in etinil estradiol. Čistilne naprave so v splošnem uspešne pri odstranjevanju večine KMES, a vseeno dosegajo v povprečju le 36 % uspešno zmanjšanje hormonske aktivnosti. Prisotnost BPA, estradiola, BPS in estrona predstavlja veliko tveganje v večini, prisotnost SS pa v desetini vzorcev RV. V obsežni študiji smo analizirali še 130 vzorcev RV in določili povišanje obremenitve s KMES, ki sledi letnemu ciklu, pri čemer je obremenitev vod pozimi kar šestkrat višja od spomladanske. Pokazali smo tudi, da šest spojin z našega nabora v okolju predstavlja tveganje, ki je višje od visokega tveganja za vsaj dva velikostna razreda. Določili smo tudi, da prisotnost BPS v pitnih vodah predstavlja visoko tveganje v kar dveh tretjinah od 25-ih testiranih vzorcev. Na celični liniji hER?-HeLa-9903 smo ob uporabi modela aditivnih koncentracij (MAK) pokazali, da sledijo estrogenski učinki zmesi MAK, med tem ko okoljski vodni vzorci izkazujejo manjšo učinkovitost od pričakovane. Pokazali smo tudi, da zmes spojin pri koncentracijah, kjer njihov učinek posamezno ni pričakovan, izkazuje merljive učinke. Na primeru modelne spojine noretindrona smo proučevali delovanje treh različnih naprednih oksidacijskih tehnik za razgradnjo in pri tem izvedli še karakterizacijo pretvorbenih produktov (PP), ki v postopku razgradnje nastanejo. Vse tri tehnike so bile učinkovite v zmanjšanju začetne koncentracije noretindrona, a so tretirani vzorci v in vitro testu pokazali zgolj delno znižanje ali celo povišanje estrogenske aktivnosti. Pri tem smo predpostavili in eksperimentalno potrdili nastanek 17-ih PP, za katere smo kot prvi s pomočjo in silico metod pokazali le deloma znižano in tudi povišano estrogensko aktivnost v primerjavi z noretindronom ter potrdili tudi prisotnost sedmih PP v okoljskih vzorcih vod. In the scope of the doctoral thesis, we have comprehensively addressed the issue of environmental pollution with hormones and some other important endocrine disruptor chemicals (EDCs). We found lacking data on the occurrence of many EDCs and their ecotoxicological potential (EP), especially synthetic steroids (SSs). On an example of bisphenol B, we showed that its EP is underestimated by at least four orders of magnitude. Therefore, to evaluate their occurrence in the environment, we have developed an ultra-sensitive analytical method for the quantitative determination of the presence of up to 25 different EDCs from the groups of natural hormones, SSs, and bisphenols. We validated the method according to an extensive protocol, which we also propose for the validation of other environmental analytical methods. We analyzed 36 samples of waste and 33 connected river waters (RW) and successfully quantified 16 EDCs, with the highest concentrations of bisphenols S, A and F, as well as estriol and chlormadinone. Concentrations above the recommended safe values were also determined for estradiol and ethinyl estradiol. Wastewater treatment plants are generally successful in removing most EDCs but achieve on average only 36% reduction in hormonal activity. The presence of BPA, estradiol, BPS and estrone poses a high risk in the majority, and the presence of SS in one tenth of RW samples. In an extensive study, we analyzed another 130 RW samples and determined the increase of EDC burden, which follows an annual cycle, whereby the burden is sixfold higher in winter than in spring. We have also shown that six compounds from our selection pose an environmental risk higher than high risk by at least two orders of magnitude. Additionally, we found that the presence of BPS in drinking water poses a high risk in two-thirds of the 25 samples tested. On the cell line hERα-HeLa-9903, using the additive concentrations model (CAM), we have shown that the estrogenic effects of mixtures follow CAM predictions, while environmental water samples show a lower efficiency than expected. We have also shown that a mixture of compounds at concentrations where their effect is not expected individually, shows measurable effects. Using norethindrone as a model compound, we studied the performance of three different advanced oxidation processes and performed the characterization of transformation products (TPs) that are formed during the degradation processes. All three treatment techniques were effective in reducing the initial concentration of norethindrone, but in vitro, the treated samples showed only a partial decrease or even an increase in estrogenic activity. Therefore, we proposed and experimentally confirmed the formation of 17 TPs, for which we were the first to show only partially reduced and also increased estrogenic activity compared to norethindrone using in silico methods. Additionally, we have confirmed the presence of seven TPs in environmental water samples.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Repository of the Un...arrow_drop_down
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    Authors: Ludovica Mana; Manel Vila-Vidal; Charlotte Köckeritz; Kevin Aquino; +3 Authors

    This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral cortex following peer review. The version of record Mana, L. et al. Using in silico perturbational approach to identify critical areas in schizophrenia. "Cerebral cortex", 15 Juny 2023, vol. 33, núm. 12, p. 7642-7658 is available online at: https://doi.org/10.1093/cercor/bhad067. Schizophrenia is a debilitating neuropsychiatric disorder whose underlying correlates remain unclear despite decades of neuroimaging investigation. One contentious topic concerns the role of global signal (GS) fluctuations and how they affect more focal functional changes. Moreover, it has been difficult to pinpoint causal mechanisms of circuit disruption. Here, we analyzed resting-state fMRI data from 47 schizophrenia patients and 118 age-matched healthy controls and used dynamical analyses to investigate how global fluctuations and other functional metastable states are affected by this disorder. We found that brain dynamics in the schizophrenia group were characterized by an increased probability of globally coherent states and reduced recurrence of a substate dominated by coupled activity in the default mode and limbic networks. We then used the in silico perturbation of a whole-brain model to identify critical areas involved in the disease. Perturbing a set of temporo-parietal sensory and associative areas in a model of the healthy brain reproduced global pathological dynamics. Healthy brain dynamics were instead restored by perturbing a set of medial fronto-temporal and cingulate regions in the model of pathology. These results highlight the relevance of GS alterations in schizophrenia and identify a set of vulnerable areas involved in determining a shift in brain state. The project that gave rise to these results received the support of a fellowship from “la Caixa” foundation “(ID 100010434)”. The fellowship code is: “(LCF/BQ/DI19/11730048)”, and financed L.M work. In addition, G.D., M.V and L.M. were supported by the Human Brain Project Specific Grant Agreement 3 Grant agreement no. “(945539)” and by the Spanish Research Project AWAKENING: using whole-brain models perturbational approaches for predicting external stimulation to force transitions between different brain states, ref. “(PID2019-105772GBI00/AEI/10.13039/501100011033)”, financed by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). G.D. and M.V. were also supported by the project “Clúster Emergent del Cervell Humà” “(CECH, ref. 001-P-001682)”, within the framework of the European Research Development Fund Operational Program of Catalonia 2014–2020. M.L.K. is supported by the Center for Music in the Brain, funded by the Danish National Research Foundation “(DNRF117)”, and Centre for Eudaimonia and Human Flourishing at Linacre College funded by the Pettit and Carlsberg Foundations. Peer Reviewed

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Cerebral Cortex
    Article . 2023 . Peer-reviewed
    License: OUP Standard Publication Reuse
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Cerebral Cortex
    Article . 2022
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao UPCommons. Portal de...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Cerebral Cortex
      Article . 2023 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Cerebral Cortex
      Article . 2022
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    Authors: Slemc, Lucija;

    Bakterija Streptomyces rimosus je poznana predvsem zaradi produkcije široko spektralnega antibiotika oksitetraciklina (OTC). Z namenom boljšega razumevanja biosinteze OTC in drugih naravnih tetraciklinov (TC) smo naredili bioinformacijsko primerjavo gruč biosinteznih genov (GBG), ki kodirajo biosintezo: OTC, klorotetraciklina, kelokardina, daktilociklina in SF2575. Nato smo se osredotočili na izbrane gene udeležene v zgodnje in pozne stopnje biosinteze OTC, katerih vloga še ni poznana. Izbili smo izbrane gene iz otc GBG (oxyI, oxyH, oxyG, oxyM, oxyO) v visoko donosnem sevu bakterije S. rimosus. Sevom z izbitimi geni smo ovrednotili donos OTC ter z analizo netarčnega metaboloma poskušali identificirati nove intermediate/stranske produkte. Pokazali smo, da geni oxyI, oxyG, oxyM in oxyO niso nujno potrebni v biosintezi OTC. Vendar ob izbitju genov oxyI, oxyG in oxyM donos OTC upade, zaradi česar domnevamo, da imajo pomožno vlogo v biosintezi. V sevu z izbitim genom oxyH je prišlo do prekinitve produkcije OTC in ob tem smo detektirali nov metabolit. V drugem sklopu smo se osredotočili na preostali sekundarni metabolizem bakterije S. rimosus, tako da smo s pomočjo bioinformacijskih orodij identificirali in analizirali GBG na kromosomu in plazmidu. Po kultivaciji bakterije S. rimosus v različnih gojiščih in LC-MS analizi smo detektirali produkcijo devetih sekundarnih metabolitov. Poleg tega smo poskušali identificirati GBG v genomu bakterije S. rimosus, ki kodira biosintezo rdeče obarvane spojine in smo jo detektirali le ob kokultivaciji z bakterijo Bacillus subtilis. Ob izbitju izbranih GBG je bakterija S. rimosus ob kokultivaciji z bakterijo B. subtilis še vedno proizvajala rdeče obarvano spojino. The bacterium Streptomyces rimosus is mainly known for the production of broad-spectrum antibiotic oxytetracycline (OTC). To gain deeper understanding of the biosynthesis of OTC and other natural tetracyclines (TC) we initialy performed a bioinformatic comparison of the biosynthetic gene clusters (BGCs) encoding the biosynthesis of OTC, chlortetracycline, chelocardin, dactylocycline and SF2575. In the second step, we focused on selected genes involved in the early and late stages of OTC biosynthesis whose roles is not yet understood. We deleted selected genes from otc BGC (oxyI, oxyH, oxyG, oxyM, oxyO) in the S. rimosus high-producer strain. We then evaluated the titer of OTC produced by engineered strains and we attempted to identify potential new intermediates or side products by analyzing the non-targeted metabolome. We showed that the oxyI, oxyG, oxyM and oxyO genes are not essential for the OTC biosynthesis. However, when the oxyI, oxyG, and oxyM genes were deleted the OTC titer decreased suggesting that these genes play an auxiliary role. OTC production was entirely disrupted in the strain with deletion of oxyH gene, instead a new metabolite was detected. In the second part of the thesis, we focused on the analysis of all BGCs encoded in the S. rimosus genom by applying bioinformatics tools. After cultivation of S. rimosus in selected media and followed by LC-MS analysis, we detected the production of nine secondary metabolites. Finally, we aimed to identify BGCs in the S. rimosus genome encoding the biosynthesis of a red-colored metabolite, which only appears in co-cultivation with Bacillus subtilis. After deletion of selected BGCs, engineered S. rimosus strains in co-cultivation with B. subtilis still produced red-colored metabolite.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Repository of the Un...arrow_drop_down
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    Authors: Favi, F;

    The aim of this paper is to suggest a new reconstruction for the stage-movements in the prologue to Lysistrata. Differently from what is generally believed, it is very unlikely that a group of non-Athenian women accompanying Lampitò, the Boeotian, and the Corinthian enters the orchestra following two other groups of Athenian women, which in turn form the chorus. On this new reconstruction, which is more faithful to the text of the play, a number of otherwise puzzling details fall into place.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Oxford University Re...arrow_drop_down
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    Rivista di Filologia e di Istruzione Classica
    Article . 2018 . Peer-reviewed
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      Rivista di Filologia e di Istruzione Classica
      Article . 2018 . Peer-reviewed
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    Authors: Yasmine Grooten; Debby Mangelings; Yvan Vander Heyden;

    Supercritical fluid chromatography (SFC) was explored as an alternative for liquid chromatography to predict the skin permeability of pharmaceutical and cosmetic compounds. Nine dissimilar stationary phases were applied to screen a test set of 58 compounds. The experimental retention factors (log k), in addition to two sets of theoretical molecular descriptors, were applied to model the skin permeability coefficient. Different modelling approaches, i.e. multiple linear regression (MLR) and partial least squares (PLS) regression, were used. In general, the MLR models performed better than the PLS models for a given descriptor set. The results obtained on a cyanopropyl (CN) column provided the best correlation with the skin permeability data. The retention factors obtained on this column were included in a simple MLR model, together with the octanol-water partition coefficient and the number of atoms (r² = 0.81, RMSEC = 0.537 or 20.5% and RMSECV = 0.580 or 22.1%). The overall best MLR model included the chromatographic descriptor from a phenyl column and 18 descriptors (r² = 0.98, RMSEC = 0.167 or 6.2% and RMSECV = 0.238 or 8.9%). This model showed a good fit, on top of very good predictive features. However, stepwise MLR models with a reduced complexity could also be determined, with the best performance parameters obtained with the CN-column based retention and eight descriptors (r² = 0.95, RMSEC = 0.282 or 10.7% and RMSECV = 0.353 or 13.4%). SFC thus provides a suitable alternative to the liquid chromatographic techniques previously applied to model the skin permeability.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Vrije Universiteit B...arrow_drop_down
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    Journal of Chromatography A
    Article . 2023 . Peer-reviewed
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      Journal of Chromatography A
      Article . 2023 . Peer-reviewed
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